TB-500
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
What is TB-500?
TB-500 is a synthetic fragment of the naturally occurring protein Thymosin Beta-4. This peptide has been extensively studied for its role in cell migration, angiogenesis, and tissue regeneration. Research applications include wound healing studies, cardiovascular research, and musculoskeletal repair investigations.
How Does TB-500 Work?
TB-500 works primarily by upregulating actin-binding proteins, which promotes cell migration, proliferation, and differentiation. It binds G-actin with high affinity, sequestering monomeric actin and facilitating cytoskeletal remodeling at wound sites. Additionally, TB-500 upregulates matrix metalloproteinases and promotes VEGF-mediated angiogenesis, enabling new blood vessel formation in ischemic or damaged tissue.
Research Applications
- Wound healing and tissue regeneration studies
- Cardiovascular repair and angiogenesis research
- Musculoskeletal injury recovery models
- Cell migration and actin polymerization studies
- Anti-inflammatory pathway investigations
Specifications
Storage & Handling
Store lyophilized peptide at -20°C. Once reconstituted, store at 4°C for up to 2 weeks or at -20°C for up to 3 months. Avoid repeated freeze-thaw cycles. Recommended reconstitution solvent: bacteriostatic water.
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
Scientific References
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11(9):421-9.
- Philp D, et al. Thymosin beta4 and a synthetic tetrapeptide AcSDKP promote dermal healing in irradiated rats. Wound Repair Regen. 2006;14(3):322-8.
- Smart N, et al. Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445(7124):177-82.
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