KVP
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
What is KVP?
KVP (Lysine-Valine-Proline) is a bioactive tripeptide sequence found within collagen molecules. This peptide is actively researched for its role in collagen synthesis, skin health studies, and connective tissue research. KVP has shown potential in promoting fibroblast activity and extracellular matrix production.
How Does KVP Work?
KVP functions by binding to collagen-related receptors on fibroblasts, stimulating the intracellular signaling cascades responsible for collagen type I and III synthesis. The proline residue in its sequence is critical for mimicking collagen's triple-helix structure, allowing it to act as a competitive signal in extracellular matrix remodeling. Studies indicate KVP also modulates matrix metalloproteinase (MMP) activity, reducing collagen degradation while simultaneously promoting new fiber deposition.
Research Applications
- Collagen synthesis and fibroblast activation studies
- Skin health and dermal remodeling research
- Extracellular matrix production investigations
- Connective tissue repair models
- Anti-aging and cellular longevity research
Specifications
Storage & Handling
Store lyophilized peptide at -20°C. Once reconstituted, store at 4°C for up to 1 week or at -20°C for up to 2 months. Avoid prolonged exposure to light. Recommended reconstitution solvent: sterile water.
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
Scientific References
- Katayama K, Armendariz-Borunda J, Raghow R. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem. 1993;268(14):9941-4.
- Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by a tripeptide from collagen. FEBS Lett. 1988;238(2):343-6.
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