Semax
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
What is Semax?
Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) fragments 4-10. This peptide has been extensively studied for its nootropic, neuroprotective, and adaptogenic properties. Research applications include cognitive function studies, neurodegenerative disease models, and stress response investigations. Semax has demonstrated potential in enhancing memory, attention, and cognitive performance.
How Does Semax Work?
Semax produces its nootropic effects through several parallel mechanisms. It significantly upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in the hippocampus, supporting neuronal survival and synaptic plasticity. Semax also modulates serotonergic, dopaminergic, and enkephalinergic neurotransmitter systems, and inhibits enkephalinase — the enzyme responsible for degrading endogenous opioid peptides. Additionally, it activates melanocortin MC4 receptors and has been shown to reduce hypoxia-induced neuronal apoptosis in animal models.
Research Applications
- Cognitive enhancement and memory studies
- Neuroprotection and neurodegeneration models
- BDNF and NGF expression research
- Stress adaptation and HPA axis investigations
- Attention and executive function studies
Specifications
Storage & Handling
Store lyophilized peptide at -20°C. Once reconstituted, store at 4°C for up to 2 weeks or at -20°C for up to 3 months. Avoid repeated freeze-thaw cycles. Recommended reconstitution solvent: sterile saline or bacteriostatic water.
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
Scientific References
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60.
- Shadrina MI, et al. Neuroprotective effect of Semax in rats in the period of reversible focal ischemia and reperfusion. Zh Nevrol Psikhiatr. 2007;107(11):77-82.
- Manchenko DM, et al. Semax affects behavior and central nervous system opioid peptides in rats. Bull Exp Biol Med. 2012;153(3):343-7.
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