Selank
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
What is Selank?
Selank is a synthetic heptapeptide derived from the natural protein tuftsin. This peptide has been researched for its anxiolytic, nootropic, and immunomodulatory effects. Studies suggest Selank may influence neurotransmitter systems involved in anxiety and stress responses while potentially enhancing cognitive function. Research applications include anxiety disorder models, stress adaptation studies, and cognitive enhancement investigations.
How Does Selank Work?
Selank exerts anxiolytic effects primarily through modulation of the GABAergic system, increasing GABA-A receptor sensitivity without causing sedation. It also normalizes the brain monoamine system, stabilizing serotonin and dopamine levels under stress conditions. As a tuftsin analog, Selank interacts with tuftsin receptors on immune cells, producing immunomodulatory effects including enhanced NK cell activity. Research shows it inhibits enkephalin-degrading enzymes, prolonging the action of endogenous anxiolytic neuropeptides.
Research Applications
- Anxiety and stress response pathway studies
- GABAergic and serotonergic system research
- Immunomodulation and tuftsin receptor investigations
- Cognitive performance and nootropic models
- Adaptogenic and anti-stress research
Specifications
Storage & Handling
Store lyophilized peptide at -20°C. Once reconstituted, store at 4°C for up to 2 weeks or at -20°C for up to 3 months. Avoid repeated freeze-thaw cycles. Recommended reconstitution solvent: sterile saline or bacteriostatic water.
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
Scientific References
- Semenova TP, et al. Effect of Selank on anxiety-related behavior and maze learning in rats with low and high exploratory activity. Bull Exp Biol Med. 2010;148(1):48-52.
- Zozulya AA, et al. The effect of a synthetic analogue of tuftsin, Selank, on enkephalin-degrading enzyme activity. Russ J Bioorg Chem. 2001;27(4):227-31.
- Uchakina ON, et al. Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr. 2008;108(5):71-5.
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