CJC-1295 (No DAC)
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
What is CJC-1295 (No DAC)?
CJC-1295 (No DAC) is a synthetic analog of growth hormone-releasing hormone (GHRH). The 'No DAC' variant lacks the Drug Affinity Complex, resulting in a shorter half-life and more physiological GH release patterns. This peptide is researched for its effects on growth hormone secretion, body composition studies, and metabolic research.
How Does CJC-1295 Work?
CJC-1295 (No DAC) binds selectively to GHRH receptors on pituitary somatotroph cells, stimulating the pulsatile release of growth hormone. Unlike the DAC version, it lacks the lysine-maleimide group that enables albumin binding, resulting in a plasma half-life of approximately 30 minutes — producing a more physiological GH pulse rather than a sustained elevation. The resulting GH release stimulates hepatic IGF-1 production, which mediates downstream anabolic and metabolic effects studied in body composition research.
Research Applications
- Growth hormone secretion and pulsatility studies
- Body composition and lean mass research
- Metabolic rate and energy expenditure models
- IGF-1 axis regulation investigations
- Pituitary function and endocrine research
Specifications
Storage & Handling
Store lyophilized peptide at -20°C. Once reconstituted, store at 4°C for up to 2 weeks or at -20°C for up to 3 months. Avoid repeated freeze-thaw cycles. Recommended reconstitution solvent: bacteriostatic water.
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications.
Scientific References
- Jetté L, et al. hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats. J Clin Endocrinol Metab. 2005;90(7):4219-26.
- Alba M, et al. Once-monthly administration of CJC-1295, a long-acting growth hormone-releasing hormone analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-4.
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